Design, synthesis and evaluation of bicyclic benzamides as novel 5-HT 1F receptor agonists

D Zhang, D Kohlman, J Krushinski, S Liang…

文献索引：Zhang, Deyi; Kohlman, Dan; Krushinski, Joseph; Liang, Sidney; Ying, Bai-Ping; Reilly, John E.; Dinn, Sean R.; Wainscott, David B.; Nutter, Suzanne; Gough, Wendy; Nelson, David L.G.; Schaus, John M.; Xu, Yao-Chang Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 24 p. 6011 - 6016

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被引用次数: 19

摘要

Several fused bicyclic systems have been investigated to serve as the core structure of potent and selective 5-HT1F receptor agonists. Replacement of the indole nucleus in 2 with indazole and 'inverted'indazole provided more potent and selective 5-HT1F receptor ligands. Indoline and 1, 2-benzisoxazole systems also provided potent 5-HT1F receptor agonists, and the 5-HT1A receptor selectivity of the indoline-and 1, 2-benzisoxazole- ...