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Structural modifications of anguidin and antitumor activities of its analogs

…, FA O'Herron, S Nachfolger, J Huftalen…

文献索引：Kaneko; Schmitz; Essery; Rose; Howell; O'Herron; Nachfolger; Huftalen; Bradner; Partyka; Doyle; Davies; Cundliffe Journal of Medicinal Chemistry, 1982 , vol. 25, # 5 p. 579 - 589

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被引用次数: 38

摘要

Approximately 60 derivatives of anguidin were prepared for evaluation of antitumor activities. Positions 3, 4, 8-10, and 15 were modified, and the resultant derivatives were screened against P-388 leukemia. It was found that introduction of the C3-keto and C3, Cgdiketo groups markedly improved the antileukemic activity, whereas epoxidation of the CW 1 0 double bond or oxidation of the C15 position diminished its activity. Selected ...

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12-epi-3α-<(tetrahydropyranyl)oxy>-12,13-epoxytrichothec-9-ene-4β,15-diol结构式

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4β-(methacryloyloxy)scirpene-3α,15-diol结构式

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4β-acetoxy-3α-O-(2-tetrahydropyranyl)scirpene-15-carboxaldehyde结构式

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4β-acetoxy-3α-hydroxyscirpene-15-carboxaldehyde结构式

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蛇形菌素标准溶液结构式

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蛇形菌素标准溶液

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4β-acetoxy-3α-hydroxyscirpene-15-carboxaldehyde结构式

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4β-hydroxy-3α-O-(2-tetrahydropyranyl)scirpene-15-carboxaldehyde结构式

81331-31-9

4β-hydroxy-3α-O...

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4β-acetoxy-3α-hydroxyscirpene-15-carboxaldehyde结构式

81331-34-2

4β-acetoxy-3α-h...

12-epi-3α-<(tetrahydropyranyl)oxy>-12,13-epoxytrichothec-9-ene-4β,15-diol结构式

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4β-acetoxy-3α-hydroxyscirpene-15-carboxaldehyde结构式

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12,13-epoxytrichothec-9-ene-3α,4β,15-triol 4β,15-diacetate 3α-tetrahydropyranyl acetal结构式

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4β-acetoxy-3α-hydroxyscirpene-15-carboxaldehyde结构式

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蛇形菌素标准溶液结构式

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蛇形菌素标准溶液

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4β-hydroxy-3α-O-(2-tetrahydropyranyl)scirpene-15-carboxaldehyde结构式

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Trichothec-9-en-15-oic acid, 12,13-epoxy-3,4-dihydroxy-结构式

81331-37-5

Trichothec-9-en...

12-epi-3α-<(tetrahydropyranyl)oxy>-12,13-epoxytrichothec-9-ene-4β,15-diol结构式

77620-41-8

12-epi-3α-<(tet...

~%

Trichothec-9-en-15-oic acid, 12,13-epoxy-3,4-dihydroxy-结构式

81331-37-5

Trichothec-9-en...

12,13-epoxytrichothec-9-ene-3α,4β,15-triol 4β,15-diacetate 3α-tetrahydropyranyl acetal结构式

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12,13-epoxytric...

~%

Trichothec-9-en-15-oic acid, 12,13-epoxy-3,4-dihydroxy-结构式

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Trichothec-9-ene-3,4,15-triol,12,13-epoxy-, (3a,4b)-结构式

2270-41-9

Trichothec-9-en...

氯乙酸酐结构式

541-88-8

氯乙酸酐

~2%

Trichothec-9-ene-3,4,15-triol, 12,13-epoxy-, 4-(chloroacetate), (3.alpha.,4.beta.)-结构式

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Trichothec-9-en...

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80178-14-9

Trichothec-9-en...

详细
4β,15-bis(methacryloyloxy)scirpene-3α,8β-diol结构式

81331-43-3

4β,15-bis(metha...

~78%

4β,15-bis(methacryloyloxy)scirpene-3,8-dione结构式

77620-59-8

4β,15-bis(metha...

蛇形菌素标准溶液结构式

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蛇形菌素标准溶液

~%

4β,15-bis(methacryloyloxy)scirpene-3,8-dione结构式

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4β,15-bis(metha...

3α,8β-bis-O-(2-tetrahydropyranyl)scirpene-4β,15-diol结构式

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3α,8β-bis-O-(2-...

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4β,15-bis(methacryloyloxy)scirpene-3,8-dione结构式

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4β,15-bis(metha...

4,15-Bis(acetyloxy)-12,13-epoxy-3-hydroxytrichothec-9-en-8-one (3alpha,4beta)-结构式

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4,15-Bis(acetyl...

~%

4β,15-bis(methacryloyloxy)scirpene-3,8-dione结构式

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4β,15-bis(metha...

新茄病镰刀菌烯醇结构式

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4β,15-bis(metha...

4β,15-diacetoxy-8α-bromoscirpen-3α-ol结构式

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4β,15-diacetoxy...

~%

4β,15-bis(methacryloyloxy)scirpene-3,8-dione结构式

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4β,15-bis(metha...

15-acetoxy-4β-(methacryloyloxy)-3α,8β-bis-O-(2-tetrahydropyranyl)scirpene结构式

81331-41-1

15-acetoxy-4β-(...

~54%

15-acetoxy-4β-(methacryloyloxy)scirpene-3α,8β-diol结构式

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15-acetoxy-4β-(...

蛇形菌素标准溶液结构式

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15-acetoxy-4β-(methacryloyloxy)scirpene-3α,8β-diol结构式

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3α,8β-bis-O-(2-tetrahydropyranyl)scirpene-4β,15-diol结构式

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15-acetoxy-4β-(methacryloyloxy)scirpene-3α,8β-diol结构式

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3α,8β-bis-O-(2-...

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4β,15-bis(methacryloyloxy)scirpene-3α,8β-diol结构式

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4β,15-bis(metha...

4,15-Bis(acetyloxy)-12,13-epoxy-3-hydroxytrichothec-9-en-8-one (3alpha,4beta)-结构式

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4,15-Bis(acetyl...

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4β,15-bis(methacryloyloxy)scirpene-3α,8β-diol结构式

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4β,15-bis(metha...

新茄病镰刀菌烯醇结构式

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新茄病镰刀菌烯醇

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4β,15-bis(methacryloyloxy)scirpene-3α,8β-diol结构式

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4β,15-bis(metha...

4β,15-diacetoxy-8α-bromoscirpen-3α-ol结构式

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4β,15-diacetoxy...

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4β,15-bis(methacryloyloxy)scirpene-3α,8β-diol结构式

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4β,15-bis(metha...

蛇形菌素标准溶液结构式

2270-40-8

蛇形菌素标准溶液

~%

3α,8β-bis-O-(2-tetrahydropyranyl)scirpene-4β,15-diol结构式

81331-40-0

3α,8β-bis-O-(2-...

4,15-Bis(acetyloxy)-12,13-epoxy-3-hydroxytrichothec-9-en-8-one (3alpha,4beta)-结构式

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4,15-Bis(acetyl...

~%

3α,8β-bis-O-(2-tetrahydropyranyl)scirpene-4β,15-diol结构式

81331-40-0

3α,8β-bis-O-(2-...

新茄病镰刀菌烯醇结构式

36519-25-2

新茄病镰刀菌烯醇

~%

3α,8β-bis-O-(2-tetrahydropyranyl)scirpene-4β,15-diol结构式

81331-40-0

3α,8β-bis-O-(2-...

4β,15-diacetoxy-8α-bromoscirpen-3α-ol结构式

81331-38-6

4β,15-diacetoxy...

~%

3α,8β-bis-O-(2-tetrahydropyranyl)scirpene-4β,15-diol结构式

81331-40-0

3α,8β-bis-O-(2-...

4β-acetoxy-3-O-(2-tetrahydropyranyl)scirpene-15-carboxaldehyde semicarbazone结构式

81331-35-3

4β-acetoxy-3-O-...

~73%

4β-acetoxy-3α-hydroxyscirpene-15-carboxaldehyde semicarbazone结构式

81331-36-4

4β-acetoxy-3α-h...

4β-hydroxy-3α-O-(2-tetrahydropyranyl)scirpene-15-carboxaldehyde结构式

81331-31-9

4β-hydroxy-3α-O...

~77%

3α,4β-dihydroxyscirpene-15-carboxaldehyde结构式

81331-32-0

3α,4β-dihydroxy...

蛇形菌素标准溶液结构式

2270-40-8

蛇形菌素标准溶液

~%

3α,4β-dihydroxyscirpene-15-carboxaldehyde结构式

81331-32-0

3α,4β-dihydroxy...

12-epi-3α-<(tetrahydropyranyl)oxy>-12,13-epoxytrichothec-9-ene-4β,15-diol结构式

77620-41-8

12-epi-3α-<(tet...

~%

3α,4β-dihydroxyscirpene-15-carboxaldehyde结构式

81331-32-0

3α,4β-dihydroxy...

12,13-epoxytrichothec-9-ene-3α,4β,15-triol 4β,15-diacetate 3α-tetrahydropyranyl acetal结构式

77620-40-7

12,13-epoxytric...

~%

3α,4β-dihydroxyscirpene-15-carboxaldehyde结构式

81331-32-0

3α,4β-dihydroxy...

Trichothec-9-ene-3,4,15-triol,12,13-epoxy-, 3,15-bis(chloroacetate), (3a,4b)- (9CI)结构式

80178-16-1

Trichothec-9-en...

~22%

3α,15-bis(chloroacetoxy)scirpen-4-one结构式

81331-27-3

3α,15-bis(chlor...

Trichothec-9-ene-3,4,15-triol,12,13-epoxy-, (3a,4b)-结构式

2270-41-9

Trichothec-9-en...

~%

3α,15-bis(chloroacetoxy)scirpen-4-one结构式

81331-27-3

3α,15-bis(chlor...

12-epi-3α-<(tetrahydropyranyl)oxy>-12,13-epoxytrichothec-9-ene-4β,15-diol结构式

77620-41-8

12-epi-3α-<(tet...

甲基丙烯酰氯结构式

920-46-7

甲基丙烯酰氯

~%

4β-(methacryloyloxy)scirpene-3α,15-diol结构式

77620-62-3

4β-(methacryloy...

Trichothec-9-ene-3,4,15-triol, 12,13-epoxy-, 15-(2-methyl-2-propenoate), (3.alpha.,4.beta.)-结构式

77620-50-9

Trichothec-9-en...

详细
15-acetoxy-4β-(methacryloyloxy)scirpene-3α,8β-diol结构式

81331-42-2

15-acetoxy-4β-(...

~78%

Trichothec-9-ene-3,8-dione,15-(acetyloxy)-12,13-epoxy-4-[(2-methyl-1-oxo-2-propenyl)oxy]-, (4b)- (9CI)结构式

77620-58-7

Trichothec-9-en...

蛇形菌素标准溶液结构式

2270-40-8

蛇形菌素标准溶液

~%

Trichothec-9-ene-3,8-dione,15-(acetyloxy)-12,13-epoxy-4-[(2-methyl-1-oxo-2-propenyl)oxy]-, (4b)- (9CI)结构式

77620-58-7

Trichothec-9-en...

3α,8β-bis-O-(2-tetrahydropyranyl)scirpene-4β,15-diol结构式

81331-40-0

3α,8β-bis-O-(2-...

~%

Trichothec-9-ene-3,8-dione,15-(acetyloxy)-12,13-epoxy-4-[(2-methyl-1-oxo-2-propenyl)oxy]-, (4b)- (9CI)结构式

77620-58-7

Trichothec-9-en...

15-acetoxy-4β-(methacryloyloxy)-3α,8β-bis-O-(2-tetrahydropyranyl)scirpene结构式

81331-41-1

15-acetoxy-4β-(...

~%

Trichothec-9-ene-3,8-dione,15-(acetyloxy)-12,13-epoxy-4-[(2-methyl-1-oxo-2-propenyl)oxy]-, (4b)- (9CI)结构式

77620-58-7

Trichothec-9-en...

4,15-Bis(acetyloxy)-12,13-epoxy-3-hydroxytrichothec-9-en-8-one (3alpha,4beta)-结构式

77620-47-4

4,15-Bis(acetyl...

~%

Trichothec-9-ene-3,8-dione,15-(acetyloxy)-12,13-epoxy-4-[(2-methyl-1-oxo-2-propenyl)oxy]-, (4b)- (9CI)结构式

77620-58-7

Trichothec-9-en...

新茄病镰刀菌烯醇结构式

36519-25-2

新茄病镰刀菌烯醇

~%

Trichothec-9-ene-3,8-dione,15-(acetyloxy)-12,13-epoxy-4-[(2-methyl-1-oxo-2-propenyl)oxy]-, (4b)- (9CI)结构式

77620-58-7

Trichothec-9-en...

4β,15-diacetoxy-8α-bromoscirpen-3α-ol结构式

81331-38-6

4β,15-diacetoxy...

~%

Trichothec-9-ene-3,8-dione,15-(acetyloxy)-12,13-epoxy-4-[(2-methyl-1-oxo-2-propenyl)oxy]-, (4b)- (9CI)结构式

77620-58-7

Trichothec-9-en...

4β,15-diacetoxy-9β,10β, 12,13-diepoxytrichothecan-3α-ol结构式

81331-28-4

4β,15-diacetoxy...

~91%

4β,15-diacetoxy-9β,10β-epoxyscirpen-3-one结构式

81331-30-8

4β,15-diacetoxy...

蛇形菌素标准溶液结构式

2270-40-8

蛇形菌素标准溶液

~%

4β,15-diacetoxy-9β,10β-epoxyscirpen-3-one结构式

81331-30-8

4β,15-diacetoxy...


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