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Structural modifications of anguidin and antitumor activities of its analogs

…, FA O'Herron, S Nachfolger, J Huftalen…

文献索引：Kaneko; Schmitz; Essery; Rose; Howell; O'Herron; Nachfolger; Huftalen; Bradner; Partyka; Doyle; Davies; Cundliffe Journal of Medicinal Chemistry, 1982 , vol. 25, # 5 p. 579 - 589

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被引用次数: 38

摘要

Approximately 60 derivatives of anguidin were prepared for evaluation of antitumor activities. Positions 3, 4, 8-10, and 15 were modified, and the resultant derivatives were screened against P-388 leukemia. It was found that introduction of the C3-keto and C3, Cgdiketo groups markedly improved the antileukemic activity, whereas epoxidation of the CW 1 0 double bond or oxidation of the C15 position diminished its activity. Selected ...

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77620-40-7

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77620-58-7

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81331-41-1

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77620-58-7

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~91%

4β,15-diacetoxy-9β,10β-epoxyscirpen-3-one结构式

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