Chemistry–A European Journal

Synthesis, characterization, and antioxidant activity of some ebselen analogues

KP Bhabak, G Mugesh

文献索引：Bhabak, Krishna P.; Mugesh, Govindasamy Chemistry - A European Journal, 2007 , vol. 13, # 16 p. 4594 - 4601

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被引用次数: 130

摘要

Abstract Simple synthetic routes for several analogues of the anti-inflammatory organoselenium drug, ebselen, are described. The compounds are characterized by 1 H, 13 C, and 77 Se NMR spectroscopy and mass spectral techniques and, in some cases, by single-crystal X-ray diffraction studies. The glutathione peroxidase (GPx)-like antioxidant activity has been studied by using H 2 O 2, tBuOOH, and Cum-OOH as substrates, and ...