Conformationally constrained analogues of diacylglycerol (DAG). 27. Modulation of membrane translocation of protein kinase C (PKC) isozymes α and δ by …

K Malolanarasimhan, N Kedei, DM Sigano…

文献索引：Malolanarasimhan, Krishnan; Kedei, Noemi; Sigano, Dina M.; Kelley, James A.; Lai, Christopher C.; Lewin, Nancy E.; Surawski, Robert J.; Pavlyukovets, Vladimir A.; Garfield, Susan H.; Wincovitch, Stephen; Blumberg, Peter M.; Marquez, Victor E. Journal of Medicinal Chemistry, 2007 , vol. 50, # 5 p. 962 - 978

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被引用次数: 18

摘要

Highly rigid and geometrically well-defined rods composed of ethynylene-substituted aromatic spacers [oligo (p-phenyleneethynylene), OPE] were incorporated as acyl moieties on diacylglycerol lactones (DAG-lactones) and investigated for their ability to bind to protein kinase C (PKC) and translocate PKC α and δ isoforms to plasma and internal membranes. The kinetics of PKC translocation were correlated with biological responses, viz. ERK ...