Organic letters

Asymmetric hydrogenation of 2-and 2, 3-substituted quinoxalines with chiral cationic ruthenium diamine catalysts

J Qin, F Chen, Z Ding, YM He, L Xu, QH Fan

文献索引：Qin, Jie; Chen, Fei; Ding, Ziyuan; He, Yan-Mei; Xu, Lijin; Fan, Qing-Hua Organic Letters, 2011 , vol. 13, # 24 p. 6568 - 6571

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被引用次数: 34

摘要

The enantioselective hydrogenation of 2-alkyl-and 2-aryl-subsituted quinoxalines and 2, 3- disubstituted quinoxalines was developed by using the cationic Ru (η6-cymene)( monosulfonylated diamine)(BArF) system in high yields with up to 99% ee. The counteranion was found to be critically important for the high enantioselectivity and/or diastereoselectivity.