Radical Catalysis of Kumada Cross??Coupling Reactions Using Functionalized Grignard Reagents

G Manolikakes, P Knochel

文献索引：Manolikakes, Georg; Knochel, Paul Angewandte Chemie - International Edition, 2009 , vol. 48, # 1 p. 205 - 209

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被引用次数: 106

摘要

The Kumada cross-coupling allows direct Pd-catalyzed carbon–carbon bond formation between unsaturated halides and organomagnesium reagents (without further transmetalation steps)[1, 2] and is therefore a highly atom-economical cross-coupling reaction.[3] Most of these cross-couplings follow a standard mechanism (oxidative addition, ligand exchange, reductive elimination),[4] although an alternative pathway is possible, as ...