Addition of boron enolates to isoquinolinium salts: A facile synthesis of 1-β-keto substituted 2-ethoxycarbonyl-1, 2-dihydroisoquinolines and their cyclization
Abstract An efficient method to synthesize 1-β-keto substituted 2-ethoxycarbonyl (or 2-acetyl)- 1, 2-dihydroisoquinolines (3) is described, utilizing boron enolates and isoquinolinium salts. The products were treated with sodium ethoxide to afford the corresponding cyclic compounds (6).
