Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B

…, JA Pollock, AM Kabadi, DG McCafferty

文献索引：Gooden, David M.; Schmidt, Dawn M.Z.; Pollock, Julie A.; Kabadi, Ami M.; McCafferty, Dewey G. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 10 p. 3047 - 3051

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被引用次数: 63

摘要

A facile synthetic route to substituted trans-2-arylcyclopropylamines was developed to provide access to mechanism-based inhibitors of the human flavoenzyme oxidase lysine- specific histone demethylase LSD1 and related enzyme family members such as monoamine oxidases A and B.