Synthesis

Solid phase synthesis of aminopropenones and aminopropenoates; efficient and versatile synthons for combinatorial synthesis of heterocycles

J Westman, R Lundin

文献索引：Westman, Jacob; Lundin, Ronny Synthesis, 2003 , # 7 p. 1025 - 1030

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被引用次数: 28

摘要

Abstract Simple and fast solid phase methods for the synthesis of heterocycles will be described. Two different three-step methods are presented. The first method includes esterifications of N-protected glycine derivatives to a solid support (Merrifield resin), formation of aminopropenoates and subsequent reaction with dinucleophiles. The second method includes methylamination of a Merrifield resin, formation of aminopropenones via ...