A series of 34 l-imidazolyl) chroman-4-ones and 24 1-imidazolyl)-1-tetralones 11, some of their alcohols, and some related compounds were synthesized and tested for hypolipidemic activity. Compounds 11, bearing appropriate lipophilic substituents on the phenyl ring, strongly reduced total serum cholesterol while raisii high-density lipoprotein cholesterol in diet-induced hypercholesterolemic rata. 3-(l-Imidazolyl) chroman-4-ols and 24 1- ...