Tetrahedron letters

Efficient method for tetrahydropyranylation/depyranylation of phenols and alcohols using a solid acid catalyst with Wells–Dawson structure

GP Romanelli, G Baronetti, HJ Thomas, JC Autino

文献索引：Romanelli, Gustavo P.; Baronetti, Graciela; Thomas, Horacio J.; Autino, Juan C. Tetrahedron Letters, 2002 , vol. 43, # 42 p. 7589 - 7591

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被引用次数: 45

摘要

A simple and efficient procedure to form 2-tetrahydropyranyl acetals of phenols and alcohols is reported. Wells–Dawson heteropolyacid catalyst is used both in bulk form or supported on silica, reaction conditions include room temperature and toluene as solvent. Fast deprotection of THP-acetals can be attained by mere change of the solvent using THF–1% MeOH. In both reactions the supported catalyst is easily recoverable and reusable, and ...