1-Amido-1-phenyl-3-piperidinylbutanes–CCR5 antagonists for the treatment of HIV: Part 2

…, RL Eastwood, DS Middleton, KA Paradowski

文献索引：Barber, Christopher G.; Blakemore, David C.; Chiva, Jean-Yves; Eastwood, Rachel L.; Middleton, Donald S.; Paradowski, Kerry A. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 5 p. 1499 - 1503

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被引用次数: 22

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Optimisation of a series of 4-piperidinyltriazoles led to the identification of compound 28a which showed good whole cell antiviral activity, excellent selectivity over the hERG ion channel and complete oral absorption. ... Optimisation of a series of compound 4-piperidinyltriazoles led to the ...