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1-Aryl-3, 4-dihydro-1H-quinolin-2-one derivatives, novel and selective norepinephrine reuptake inhibitors

…, N Dezutter, J Findlay, L Hayhurst, JJ Masters…

文献索引:Beadle, Christopher D.; Boot, John; Camp, Nicholas P.; Dezutter, Nancy; Findlay, Jeremy; Hayhurst, Lorna; Masters, John J.; Penariol, Roberta; Walter, Magnus W. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 20 p. 4432 - 4437

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被引用次数: 24

摘要

A novel series of 1-aryl-3, 4-dihydro-1H-quinolin-2-ones have been discovered as potent and selective norepinephrine reuptake inhibitors. Efficient synthetic routes have been developed which allow for the multi-gram preparation of both final targets and advanced intermediates for SAR expansion.

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