Organic letters

Mercury-free preparation and selective reactions of propargyl (and propargylic) Grignard reagents

HP Acharya, K Miyoshi, Y Kobayashi

文献索引：Acharya, Hukum P.; Miyoshi, Kei; Kobayashi, Yuichi Organic Letters, 2007 , vol. 9, # 18 p. 3535 - 3538

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被引用次数: 36

摘要

ZnBr2 was found to catalyze formation of propargyl and propargylic Grignard reagents, and thus put an end to the standard method using a mercury catalyst. The Grignard reagents were submitted to addition reaction with carbonyl compounds and allylation with the cyclic monoacetate to afford the propargyl-type products selectively. Furthermore, the product from the monoacetate was transformed to an acetylene analogue of 2-(5, 6-epoxyisoprostane ...