Synthesis and cyclooxygenase inhibitory activities of linear 1-(methanesulfonylphenyl or benzenesulfonamido)-2-(pyridyl) acetylene regioisomers

…, Y Dong, QH Chen, KRA Abdellatif, EE Knaus

文献索引：Chowdhury, Morshed Alam; Dong, Ying; Chen, Qiao-Hong; Abdellatif, Khaled R.A.; Knaus, Edward E. Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 4 p. 1948 - 1956

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被引用次数: 11

摘要

A group of 1-(aminosulfonylphenyl and methylsulfonylphenyl)-2-(pyridyl) acetylene regioisomers were designed such that a COX-2 SO2NH2 pharmacophore was located at the para-position of the phenyl ring, or a SO2Me pharmacophore was placed at the ortho-, meta- or para-position of the phenyl ring, on an acetylene template (scaffold). The point of attachment of the pyridyl ring to the acetylene linker was simultaneously varied (2-pyridyl, ...