Sterically hindered chelating alkyl phosphines provide large rate accelerations in palladium-catalyzed amination of aryl iodides, bromides, and chlorides, and the first …

BC Hamann, JF Hartwig

文献索引：Hamann; Hartwig Journal of the American Chemical Society, 1998 , vol. 120, # 29 p. 7369 - 7370

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被引用次数: 375

摘要

Aromatic phosphines and arsines are typically used as ligands in synthetically valuable palladium-catalyzed cross-coupling processes that include recently developed couplings to form arylamines and aryl ethers from aryl halides and triflates. 1-3 We have recently sought palladium systems comprised of air stable components that provide faster reaction rates for aryl bromide and iodide amination and allow the amination of less activated and ...