Il Farmaco

Synthesis, lipophilicity and biological evaluation of indole-containing derivatives of 1, 3, 4-thiadiazole and 1, 2, 4-triazole

A Varvaresou, T Siatra-Papastaikoudi, A Tsotinis…

文献索引：Varvaresou, Athanasia; Siatra-Papastaikoudi, Theodora; Tsotinis, Andrew; Tsantili-Kakoulidou, Anna; Vamvakides, Alexandre Farmaco, 1998 , vol. 53, # 5 p. 320 - 326

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被引用次数: 129

摘要

3-[(2-Methyl-1H-3-indolyl) methyl]-4-aryl-4, 5-dihydro-1H-1, 2, 4-triazole-5-thiones 6a-c and their respective N-{5-[(2-methyl-1H-3-indolyl) methyl]-1, 3, 4-thiadiazol-2-yl}-N-arylamines 7a, b have been prepared. The antidepressant profile of 6a, c and 7a was studied on mice with respect to that of the analogous 3-(1H-1-indolylmethyl)-4-aryl-4, 5-dihydro-1H-1, 2, 4- triazole-5-thiones 1a-c and the respective N-15 {(2-methyl-1H-3-indolyl) methyl]-1, 3, 4- ...