Inhibitors of gastric acid secretion: 3, 4-diamino-1, 2, 5-thiadiazole 1-oxides and 1, 1-dioxides as urea equivalents in a series of histamine H2 receptor antagonists

…, PS Anderson, JJ Baldwin, WA Bolhofer…

文献索引：Lumma, William C.; Anderson, Paul S.; Baldwin, John J.; Bolhofer, William A.; Habecker, Charles N.; et al. Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 207 - 210

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被引用次数: 42

摘要

0" la, R= CH,; n= 1 b, R= H; n= 2 c, R= H; n= 2 synthesis of 3, 4-diamino-1, 2, 5-thiadiazole 1, l-dioxides and their weakly acidic amide-like properties; more recently, the chemistry of the corresponding" sulfoxide analogues" or l-oxides was developed by Weinstock and co- workers8 in these laboratories. Compounds la-f were synthesized by reacting the known amines R'NH,(Table I) with the appropriate synthon 2 in a polar solvent such as ...