2-Benzodioxinylaminoethanol: a new class of. beta.-adrenergic blocking and antihypertensive agents

…, G Coudert, G Guillaumet, B Loubinoux…

文献索引：Lalloz, Lucien; Loppinet, Vincent; Coudert, Gerard; Guillaumet, Gerald; Loubinoux, Bernard; et al. Journal of Medicinal Chemistry, 1981 , vol. 24, # 8 p. 994 - 998

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被引用次数: 20

摘要

Various 2-benzodioxinylaminothanol derivatives were synthetized and investigated for 0- adrenergic blocking activity. Most compounds demonstrated a p-blocking activity of a competitive type when evaluated'in guinea pig atrial and tracheal preparations. Three compounds were more potent than practolol and propranolol. All compounds demonstrated antihypertensive properties in spontaneously hypertensive rats. The most active ...