High affinity central benzodiazepine receptor ligands: synthesis and structure–activity relationship studies of a new series of pyrazolo [4, 3-c] quinolin-3-ones

L Savini, P Massarelli, C Nencini, C Pellerano…

文献索引：Savini; Massarelli; Nencini; Pellerano; Biggio; Maciocco; Tuligi; Carrieri; Cinone; Carotti Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 4 p. 389 - 399

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被引用次数: 34

摘要

A large series of 2-aryl (heteroaryl)-2, 5-dihydropyrazolo [4, 3-c] quinolin-3-(3H)-ones, carrying appropriate substituents at the quinoline and N2-phenyl rings, were prepared and tested as central benzodiazepine receptor ligands. Results from structure–affinity relationship studies were in full agreement with previously proposed pharmacophore models and, in addition, quantitative structure–activity analysis gave further significant ...