Neuromuscular blocking agents. Approaches to short-acting compounds 2. Bis-thiazolium salts

…, RB Maehr, J Scharver, WB Wastila…

文献索引：Stenlake, J B; Dhar, N C; Haddow, J; McDonald, I M; Maehr, R B; Wastila, W B European Journal of Medicinal Chemistry, 1992 , vol. 27, # 5 p. 463 - 477

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被引用次数: 12

摘要

Abstract A series of bis-thiazolium diesters has been prepared. All were substantially less potent than atracurium and all showed appreciable vagal blockade at neuromuscular blocking doses. N-Benzyl quaternary substituents shortened the duration of neuromuscular blockade significantly. Neuromuscular blocking potency was greater and duration of action least in bis-N-3, 4, 5-trimethoxybenzylthiazolium salts, though each of these effects was at ...