Marine drugs

Synthesis and α-glucosidase inhibitory mechanisms of bis (2, 3-dibromo-4, 5-dihydroxybenzyl) ether, a potential marine bromophenol α-glucosidase inhibitor

M Liu, W Zhang, J Wei, X Lin

文献索引：Liu, Ming; Zhang, Wei; Wei, Jianteng; Lin, Xiukun Marine Drugs, 2011 , vol. 9, # 9 p. 1554 - 1565

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被引用次数: 22

摘要

Abstract: Bis (2, 3-dibromo-4, 5-dihydroxybenzyl) ether (BDDE), derived from the marine algae, is a potential α-glucosidase inhibitor for type 2 diabetes treatment. In the present study, a synthetic route was established as a valid approach to obtain BDDE. Fluorescence spectra, circular dichroism spectra and molecular docking methods were employed to elucidate the inhibitory mechanisms of BDDE against α-glucosidase. The results showed ...