Inhibition of plasminogen activator inhibitor-1 activity by two diketopiperazines, XR330 and XR334 produced by Streptomyces sp.

…, P CHARLTON, I CHICARELLI-ROBINSON…

文献索引：Bryans, Justin; Charlton, Peter; Chicarelli-Robinson, Ines; Collins, Mark; Faint, Richard; Latham, Chris; Shaw, Ian; Trew, Sally Journal of Antibiotics, 1996 , vol. 49, # 10 p. 1014 - 1021

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被引用次数: 49

摘要

Two diketopiperazines, XR334 (1) and the novel compound XR330 (2), were isolated from the lyophilised biomass of an unidentified Streptomyces sp. Their structures were elucidated on the basis of spectroscopic studies and confirmed by chemical synthesis. Both compounds inhibited plasminogen activator inhibitor-1 activity in an amidolytic assay of tissue plasminogen activator mediated plasmin generation. Compound 1 also enhanced ...