Synthesis and Antibiofilm Activity of a Second??Generation Reverse??Amide Oroidin Library: A Structure–Activity Relationship Study

…, JJ Richards, AL Wolfe, C Melander

文献索引：Eric Ballard; Richards, Justin J.; Wolfe, Amanda L.; Melander, Christian Chemistry - A European Journal, 2008 , vol. 14, # 34 p. 10745 - 10761

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被引用次数: 65

摘要

Abstract A second-generation library of 2-aminoimidazole-based derivatives incorporating a “reversed amide”(RA) motif in comparison to the marine natural product oroidin were synthesized and subsequently assayed for antibiofilm activity against the medically relevant Gram-negative proteobacteria P. aeruginosa and A. baumannii. Most notably, an in-depth activity profile is reported for the most active subclass of derivatives that bear linear ...