Total synthesis of the quinonoid alcohol dehydrogenase coenzyme (1) of methylotrophic bacteria

EJ Corey, A Tramontano

文献索引：Corey,E.J.; Tramontano,A. Journal of the American Chemical Society, 1981 , vol. 103, p. 5599

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被引用次数: 125

摘要

Methylotrophic bacteria which can survive by using one-carbon compounds such as methane or methanol as the sole carbon source contain a novel alcohol dehydrogenase which is neither NAD nor flavin dependent. The coenzyme for this dehydrogenase has recently been assigned structure 1 on the basis of an X-ray diffraction study of a derivative'and other evidence. 24 Only a few milligrams of this unique cofactor have been ...