Tetrahedron

Synthesis of 2-aminobenzoxazoles via copper-catalyzed electrophilic amination of benzoxazoles with O-benzoyl hydroxylamines

S Yotphan, D Beukeaw, V Reutrakul

文献索引：Yotphan, Sirilata; Beukeaw, Danupat; Reutrakul, Vichai Tetrahedron, 2013 , vol. 69, # 32 p. 6627 - 6633

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被引用次数: 14

摘要

An efficient copper-catalyzed electrophilic amination of benzoxazoles with O-benzoyl hydroxylamines is described, employing CuCl catalyst, PPh3 ligand, and LiOtBu base. This simple air-stable copper catalysis enables the preparation of various 2-aminobenzoxazole derivatives at room temperature in good yields.