Photoinduced Upregulation of Calcitonin Gene-Related Peptide in A549 Cells through HNO Release from a Hydrophilic Photocontrollable HNO Donor

K Matsuo, H Nakagawa, Y Adachi, E Kameda…

文献索引：Matsuo, Kazuya; Nakagawa, Hidehiko; Adachi, Yusuke; Kameda, Eri; Aizawa, Kazuyuki; Tsumoto, Hiroki; Suzuki, Takayoshi; Miyata, Naoki Chemical and Pharmaceutical Bulletin, 2012 , vol. 60, # 8 p. 1055 - 1062

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被引用次数: 6

摘要

Nitroxyl (HNO), a one-electron-reduced form of nitric oxide, has various biological activities, including a cardioprotective effect. Here, we first synthesized another, more hydrophilic photocontrollable HNO donor (3), which can release HNO in a spatially and temporally controlled manner, and then examined the properties of our series of compounds as practical HNO donors in a cellular system under photocontrol. We selected compound 2 ...