(−)-Carbodine: Enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 ( …

JR Rao, AK Jha, RK Rawal, A Sharon, CW Day…

文献索引：Rao, Jagadeeshwar R.; Jha, Ashok K.; Rawal, Ravindra K.; Sharon, Ashoke; Day, Craig W.; Barnard, Dale L.; Smee, Donald F.; Chu, Chung K. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 8 p. 2601 - 2604

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被引用次数: 11

摘要

Enantiomerically pure cyclopentyl cytosine [(−)-carbodine 1] was synthesized from d-ribose and evaluated for its anti-influenza activity in vitro in comparison to the (+)-carbodine,(±)- carbodine and ribavirin.(−)-Carbodine 1 exhibited potent antiviral activity against various strains of influenza A and B viruses.