A flow-based synthesis of 2-aminoadamantane-2-carboxylic acid

C Battilocchio, IR Baxendale, M Biava…

文献索引：Battilocchio, Claudio; Baumann, Marcus; Baxendale, Ian R.; Biava, Mariangela; Kitching, Matthew O.; Ley, Steven V.; Martin, Rainer E.; Ohnmacht, Stephan A.; Tappin, Nicholas D. C. Synthesis, 2012 , vol. 44, # 4 p. 635 - 647

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被引用次数: 35

摘要

The development of a new, high-yielding, scalable and safe process for the preparation of 2- aminoadamantane-2-carboxylic acid (1) is described. This geminal, functionalized achiral amino acid has been reported to possess interesting biological activity as a transport mediator due to its unique physiochemical properties. We report herein on the use of various mesoreactor flow devices to expedite the lab-scale synthesis of this molecule by ...