Synthesis of sceletium and amaryllidaceae alkaloids,(.+-.)-mesembrine and (.+-.)-dihydromaritidine,(.+-.)-epidihydromaritidine,(.+-.)-elwesine, and (.+-.)-epielwesine.

…, N SHIMAMURA, A ONODERA, B UMEZAWA

文献索引：Hoshino, Osamu; Sawaki, Shohei; Shimamura, Naomi; Onodera, Akira; Umezawa, Bunsuke Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 7 p. 2734 - 2743

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被引用次数: 17

摘要

The alkylation of 2-arylcyclohexanones (12b and 6) with alkyl halides or acrylonitrile and 50% aq. sodium hydroxide in the presence of a phase-transfer catalyst (18-crown-6) was found to give readily 2-alkyl-2-arylcyclohexanones (14 and 16) in fair to good yields. Furthermore, 2-allyl-2-aryl-5, 5-ethylenedioxycyclohexanone (16a or 16b) was coverted into (±)-mesembrine (1),(±)-dihydromaritidine (4a), and (±)-epidihydromaritidine (5a) or (±)- ...