Regioselectivity in a highly efficient, microwave-assisted epoxide aminolysis

…, BR D'Souza, D Foether, BF Johnson, HA Lindsay

文献索引：Desai, Hinal; D'Souza, Brendan R.; Foether, Devin; Johnson, Benjamin F.; Lindsay, Harriet A. Synthesis, 2007 , # 6 p. 902 - 910

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被引用次数: 26

摘要

Abstract We have developed a microwave-assisted aminolysis of epoxides as an efficient method for synthesizing a number of β-amino alcohols. In most cases, including in reactions of amines with a trisubstituted epoxide, only one equivalent of amine is required to obtain good yields. The reactions are consistently regioselective for amine nucleophiles of varying strengths and for both hindered and unhindered epoxides. In some cases, this ...