A series of 4-aminomethylpyridazines and-pyridazin-3 (2H)-ones (“diaza-benzylamines”), bearing alkylamino side chains in ortho position relative to the CH 2 NH 2 unit, was synthesized by catalytic hydrogenation of the corresponding nitriles in strongly acidic medium. N-Benzyl protecting groups either at the pyridazinone ring nitrogen or at an exocyclic nitrogen were selectively removed hydrogenolytically or by treatment with a ...
