Bioorganic & medicinal chemistry letters

A facile solid phase synthesis of tetramic acid

Z Liu, X Ruan, X Huang

文献索引：Liu, Zhanxiang; Ruan, Xiuxiu; Huang, Xian Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 15 p. 2505 - 2507

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被引用次数: 17

摘要

The condensation of N-acylated amino acids with polymer-supported cyclic malonic acid ester was carried out in the presence of DCC/DMAP. The cyclisation of the intermediate resin, by heating in an organic solvent, gave the N-protected tetramic acid derivatives in good yields and high purity.