Synlett

A tandem ring-closing metathesis cleavable linker system for solid-phase oligosaccharide synthesis

…, HS Overkleeft, JH van Boom, GA van der Marel

文献索引：Timmer, Mattie S. M.; Codee, Jeroen D. C.; Overkleeft, Herman S.; Van Boom, Jacques H.; Van Der Marel, Gijsbert A. Synlett, 2004 , # 12 p. 2155 - 2158

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被引用次数: 12

摘要

Abstract A novel triene linker system, that can be cleaved by a tandem ring-closing metathesis (RCM) reaction, is presented. The tandem RCM cleavage, that regenerates the active ruthenium catalyst without the need of additives like ethylene, proceeded very clean and fast to liberate cyclopent-2-enyl mannosides from the solid support. A cyclopent-2-enyl mannoside was isomerized to the corresponding vinyl ether glycoside, which could be ...