The “fatty acid cycle,” which governs fat metabolism in vivo, has been duplicated using simplified model compount s containing the structural elements which are considered important to the activity of coenzyme A. The reactions i dude Claisen-type self-condensation of N, S-diacetylthioethanolamine (I) to N-acetyl-S-acetoacetylthioethanolamine (I1 [), reduction of the latter to N-acetyl-S-/3-hydroxybutyrylthioethanolamine(IV), dehydration of ...
