Human alcohol dehydrogenase (Hs ADH) comprises class I (α, β, and γ), class II (π), and class IV (σ) enzymes. Selective inhibitors of the enzymes could be used to prevent the metabolism of alcohols that form toxic products. Formamides are unreactive analogues of aldehydes and bind to the enzyme-NADH complex [Ramaswamy, S.; Scholze, M.; Plapp, BV Biochemistry 1997, 36, 3522-3527]. They are uncompetitive inhibitors against varied ...
