Antiproliferative Diarylpyrazole Derivatives as Dual Inhibitors of the ERK Pathway and COX??2

MI El??Gamal, HS Choi, KH Yoo…

文献索引：El-Gamal, Mohammed I.; Choi, Hong Seok; Yoo, Kyung Ho; Baek, Daejin; Oh, Chang-Hyun Chemical Biology and Drug Design, 2013 , vol. 82, # 3 p. 336 - 347

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被引用次数: 7

摘要

A series of 3, 4-diarylpyrazole-1-carboxamide derivatives was designed and synthesized. A selected group of the target compounds was tested for in vitro antiproliferative activities over a panel of 60 cancer cell lines at the National Cancer Institute (NCI, Bethesda, MD, USA) at a single-dose concentration of 10 lM, and the four most active compounds 9a, 9l, 9n, and 10o were further tested in a five-dose testing mode to determine their IC50 values over the ...