Synlett

Oxidative deprotection of 1, 3-dithiane group using NaClO2 and NaH2PO4 in aqueous methanol

T Ichige, A Miyake, N Kanoh, M Nakata

文献索引：Ichige, Takahiro; Miyake, Annu; Kanoh, Naoki; Nakata, Masaya Synlett, 2004 , # 10 p. 1686 - 1690

全文：HTML全文

被引用次数: 16

摘要

We selected silyl ether 3a, prepared from 1,3-propanediol via alcohol 3b as shown in Scheme [2] , as the model compound. First, solvent (0.2 M for 3a) optimization was investigated (Table [1] ) using 6 molar amounts of NaClO 2 , [9] 2 molar amounts of NaH 2 PO 4 , [10] and 10 molar amounts of 2-methyl-2-butene at room temperature for the indicated reaction time. As shown in Table [1] , alcoholic solvents were suitable for this reaction (entries 7-10); among them, ...