Tetrahedron Letters

Regiospecific monoalkylation of 3-butenenitrile

GR Kieczykowski, RH Schlessinger, RB Sulsky

文献索引：Kieczykowski,G.R. et al. Tetrahedron Letters, 1975 , # 52 p. 4647 - 4650

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被引用次数: 6

摘要

I that the lithium enolate derived from 1 undergoes only dialkylation under a variety of conditions (a result of rapid anion exchange). 1 These results were incompatible with our synthetic needs and prompted us to examine the possibility of realizing stepwise and regiospecific alkylation of 1. Herein, we report the results of this investigation.