Abstract N, N-diethyl methacrylamide (1) undergoes hydroformylation, followed by subsequent reactions, under “oxo” conditions involving use of Rh 4 (CO) 12 or Rh 4 (CO) 12 in the presence of (R, R)-Diop (Diop= 2, 2-dimethyl-1, 3-dioxolane-4, 5-diylbis (methylene) bis (diphenylphosphine)) as the catalyst precursor. The product first formed arises from formylation at the unsubstituted unsaturated carbon atom, and subsequently gives α- ...
