Synthesis and hypotensive activity of N-alkyl-N''-cyano-N'-pyridylguanidines

HJ Petersen, CK Nielsen…

文献索引：Petersen,H.J. et al. Journal of Medicinal Chemistry, 1978 , vol. 21, p. 773 - 781

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被引用次数: 147

摘要

chloride, mp 138-140 “C. Anal.(CloHl6ClNS) C, H, N. 1, l-Dimet hyl-2-(phenylsulfiny1) et hylamine (58). 1, l-Di-methyL2-(phenylthio) ethylamine hydrochloride (1.1 g, 0.005 mol) was added in one portion to an ice-cold stirred solution of sodium periodate (1.1 g, 0.005 mol) in aqueous methanol (30 mL, 1: l). The reaction mixture was stirred at ambient temperature for 48 h and filtered. The filtrate was concentrated under reduced pressure and the residue ...