Preparation and biological activity of 6-benzylaminopurine derivatives in plants and human cancer cells

…, M Fojtíková, J Holub, R Lenobel, T Schmülling…

文献索引：Dolezal, Karel; Popa, Igor; Krystof, Vladimir; Spichal, Lukas; Fojtikova, Martina; Holub, Jan; Lenobel, Rene; Schmuelling, Thomas; Strnad, Miroslav Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 3 p. 875 - 884

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被引用次数: 92

摘要

To study the structure–activity relationships of aromatic cytokinins, the cytokinin activity at both the receptor and cellular levels, as well as CDK inhibitory and anticancer properties of 38 6-benzylaminopurine (BAP) derivatives were compared in various in vitro assays. The compounds were prepared by the condensation of 6-chloropurine with corresponding substituted benzylamines. The majority of synthesised derivatives exhibited high activity in ...