Can innate immune system targets turn up the heat on 'cold' tumours? Can innate immune system targets turn up the heat on 'cold' tumours?, Published online: 28 December 2018; doi:10.1038/nrd.2017.264STING, RIG-I and NLRP3 agonists might increase the effectiveness of immuno-oncology checkpoint inhibitors, while antagonists of these targets offer an anti-inflammatory bonus.