The structural basis for the narrow substrate specificity of an acetyl esterase from Thermotoga maritima

MK Hedge, AM Gehring, CT Adkins, LA Weston…

文献索引：Hedge, Matthew K.; Gehring, Alexandra M.; Adkins, Chinessa T.; Weston, Leigh A.; Lavis, Luke D.; Johnson, R. Jeremy Biochimica et Biophysica Acta - Proteins and Proteomics, 2012 , vol. 1824, # 9 p. 1024 - 1030

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被引用次数: 14

摘要

Acetyl esterases from carbohydrate esterase family 7 exhibit unusual substrate specificity. These proteins catalyze the cleavage of disparate acetate esters with high efficiency, but are unreactive to larger acyl groups. The structural basis for this distinct selectivity profile is ...