Abstract Cyclization of thiocyanomethylketone oximes with hydroxylamine hydrochloride and oxidation of 2-aminothiazole derivatives with peracids are shown to afford the same products, which can be formulated either as 2-imino-3-hydroxy-2, 3-dihydrothiazolines or 2- aminothiazole N-oxides. Compounds of this type bearing at position 4 an acetic or α- oxyiminoacetic residue are useful synthons for highly active β-lactam antibiotics; the ...
