Selenocyanates and diselenides: a new class of potent antileishmanial agents

…, D Moreno-Mateos, M Font, A Jiménez-Ruiz…

文献索引：Plano, Daniel; Baquedano, Ylenia; Moreno-Mateos, David; Font, Maria; Jimenez-Ruiz, Antonio; Palop, Juan Antonio; Sanmartin, Carmen European Journal of Medicinal Chemistry, 2011 , vol. 46, # 8 p. 3315 - 3323

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被引用次数: 50

摘要

Abstract Thirty five selenocyanate and diselenide compounds were subjected to in vitro screening against Leishmania infantum promastigotes and the most active ones were also tested in an axenic amastigote model. In order to establish the selectivity indexes (SI) the cytotoxic effect of each compound was also assayed against Jurkat and THP-1 cell lines.