We have synthesized the first surface plasmon resonance (SPR) sensor that detects cytosine-cytosine (CC) mismatches in duplex DNA by immobilizing aminonaphthyridine dimer on the gold surface. The ligand consisting of two 2-aminonaphthyridine chromophores and an alkyl linker connecting them strongly stabilized the CC mismatches regardless of the flanking sequences. The fully matched duplexes were not stabilized at all under the same ...
