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Naphthoquinone antimalarials. XIV. 2-Hydroxy-3-aryl-1, 4-naphthoquinones

HE Zaugg, RT Rapala, MT Leffler

文献索引:Zaugg; Rapala; Leffler Journal of the American Chemical Society, 1948 , vol. 70, p. 3224,3226

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被引用次数: 16

摘要

The observation'that 2-hydroxy-3-phenyl-l, 4-ported that p-chlorophenylacetic ester gave the naphthoquinone2 (IV, R1= Rz= Rs= H) has an corresponding/3-keto-ester (11) in good yield with activity approximately one-fourth that of quinine isopropylmagnesium bromide as a catalyst5 but against P. lophurae in ducks, prompted further in-did not react in the presence of sodium ethoxide. vestigation in this series. Therefore the former reagent was chosen for ...