Functionalized amido ketones: new anticonvulsant agents

…, SV Andurkar, AY Jin, JP Stables, DF Weaver…

文献索引：Beguin, Cecile; Andurkar, Shridhar V.; Jin, Albert Y.; Stables, James P.; Weaver, Donald F.; Kohn, Harold Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 19 p. 4275 - 4285

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被引用次数: 17

摘要

We have reported that functionalized amino acids (FAA) are potent anticonvulsants. Replacing the N-terminal amide group in FAA with phenethyl, styryl, and phenylethynyl units provided a series of functionalized amido ketones (FAK). We show that select FAK exhibit significant anticonvulsant activities thereby providing information about the structural requirements for FAA and FAK bioactivity.