Synthesis

Synthesis of new arylhydroxymethylphosphinic acids and derivatives

HJ Cristau, A Hervé, F Loiseau, D Virieux

文献索引：Cristau; Herve; Loiseau; Virieux Synthesis, 2003 , # 14 p. 2216 - 2220

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被引用次数: 19

摘要

Abstract The synthesis of a new series of arylhydroxymethylphosphinic acid derivatives is described. The protected compounds were prepared by a palladium (0) catalysed arylation of ethyl benzyloxymethylphosphinate with aryl halides. Subsequent hydrogenolysis of the benzyl protecting group followed by acidic hydrolysis of the ester function readily afforded the target compounds. Selective removal of the ester group was achieved by basic ...